What is CML

Chronic myeloid leukemia (CML) is a type of cancer that begins in the bone marrow and spills into the blood, impacting the production of white blood cells known as myeloid cells. These cells grow and divide uncontrollably, crowding out normal cells, which disrupts many of the body’s regular functions. The progression of CML is often slow, spanning over months or years, making prompt diagnosis and treatment crucial.

Globally, CML accounts for 15-20% of all adult leukemias. Although CML can affect individuals of all ages, its prevalence is higher among adults, particularly those in their mid-60s. Genetic mutations, especially the Philadelphia chromosome, are closely associated with the condition, but the exact cause remains elusive. While the disease can occur due to factors beyond one’s control, understanding its nuances is the first step toward proactive management.

Common Side Effects of CML Treatment

CML treatment primarily focuses on targeting the BCR-ABL protein, the hallmark of this disease. While these treatments have revolutionized the prognosis for CML patients, they come with a range of side effects. The most commonly reported side effect is fatigue, which can significantly impact daily activities and overall quality of life. Nausea is another prevalent side effect, sometimes accompanied by vomiting. Many patients also experience muscle and joint pain, making even simple movements challenging. Fluid retention, leading to swelling in the legs or around the eyes, is also frequently observed. Rashes and other skin reactions may manifest as itchiness or dry skin. Additionally, some treatments can cause abdominal pain, diarrhea or headaches. While these side effects are typically manageable and vary in intensity, it’s crucial for patients to communicate with their physician and healthcare team, whether at Sheba or any other medical center, so that they may adjust treatments or implement supportive measures as needed.

Open Communication with Healthcare Providers

Maintaining open and candid communication with healthcare professionals is paramount when navigating the challenges of CML. As CML treatment can often present a range of side effects, patients must feel comfortable sharing their experiences, concerns and questions with their healthcare providers. By doing so, they enable their care team to make informed decisions, optimize treatment regimens, and ensure the best possible outcomes. Beyond treatment logistics, maintaining transparent dialogue strengthens the trust between the patient and their care team, fostering a collaborative approach to managing and potentially overcoming CML.