- Radiation exposure
- Exposure to pesticides and certain other chemicals
- Autoimmune diseases, such as HIV infection
- Age of 60 or older
NHL typically develops in the lymphatic tissues and lymph nodes and can be either aggressive or indolent, meaning it progresses slowly.
NHL is divided into three major types. B-cell lymphoma begins in the B lymphocytes, cells that produce antibodies in the immune system, and makes up about 85% of all NHL cases. T-cell lymphoma affects T lymphocytes, while NK-cell lymphoma involves natural killer cells, responsible for attacking cancer cells and cells infected by viruses.