Can multiple myeloma turn into leukemia?

While multiple myeloma and leukemia are both cancers of the blood and bone marrow, they arise from different types of cells. Multiple myeloma originates from plasma cells, while leukemia starts in the early forms of white blood cells. It’s rare for myeloma to “turn into” leukemia. However, some treatments for multiple myeloma, especially certain chemotherapies, might slightly increase the risk of developing treatment-related secondary leukemia.