Does multiple myeloma cause anemia?

Anemia, a decrease in the number of red blood cells, is a common symptom in patients with multiple myeloma. The disease can interfere with the bone marrow’s ability to adequately produce red blood cells. Additionally, the kidney damage associated with myeloma can reduce the production of erythropoietin, a hormone that stimulates red blood cell production. Symptoms of anemia can include fatigue, pallor and shortness of breath. Treatment options for anemia in myeloma patients may include erythropoiesis-stimulating agents, iron supplementation or blood transfusions.