FAQ: Do CAR T-cells proliferate?

Yes, CAR T-cells can proliferate in the body. After infusion into the patient, CAR T-cells continue to multiply and expand in numbers, creating a strong and sustained immune response against the targeted cancer cells. This proliferation is essential for the CAR T-cells to effectively locate and destroy cancer cells throughout the body. However, excessive proliferation can lead to side effects such as cytokine release syndrome (CRS) and neurotoxicity. Therefore, close monitoring and management of CAR T-cell proliferation are crucial during and after the treatment process.