FAQ: Are CAR T-cells CD4 or CD8?

CAR T-cells can be engineered from either CD4+ T-cells or CD8+ T-cells, both of which are subtypes of T-cells with distinct functions. CD4+ T-cells play a role in coordinating the immune response and supporting other immune cells, while CD8+ T-cells are primarily responsible for directly killing infected or cancerous cells. Depending on the specific cancer type and therapeutic goals, researchers may choose to use CD4+ or CD8+ T-cells for CAR T-cell therapy to optimize the immune response against the cancer.