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Cutting-Edge Treatment Options for Adult Acute Leukemia Patients in Israel

Adult Acute Leukemia Treatment in Israel

Acute lymphoblastic leukemia (ALL) is a type of cancer that affects blood-forming tissues. This includes both the lymphatic system and the bone marrow. ALL harms white blood cells, which can seriously impede the body’s ability to fight off infection, and is most commonly found in children under the age of 15: accounting for around 85% of all cases. Only about 1000 ALL cases are reported annually in the USA and under 800 in the UK, making it a rare malignancy. However, due to its aggressive nature, acute lymphoblastic leukemia requires prompt treatment both in children and adults. If left untreated, ALL can be fatal within months if left untreated, quickly spreading to the nervous system, skin, spleen, bone marrow, blood, or lymph nodes.

CAR T-Cell therapy is among cutting-edge treatment options for adult acute leukemia.

Types of Acute Lymphoblastic Leukemia

The type of ALL will dictate the approach doctors take to treat the malignancy. Acute lymphoblastic leukemia can be classified into two main subtypes based on what subset of lymphocytes (white blood cells) it attacks.

  • B-cell ALL, accounting for about 85% of all cases, affects B lymphocytes that develop in the bone marrow. B lymphocytes have a major role in antibody creation and fighting off illnesses.
  • T-cell ALL attacks T lymphocytes. Unlike B lymphocytes, which mature in the bone marrow, T lymphocytes mature in the thymus (part of the lymphatic system). This is the less common type of ALL, accounting for about 15% of cases.
  • ALL Symptoms

    A low blood count of normal cells is one of the leading indicators of ALL. This happens because healthy blood cells are overrun by leukemia cells. Symptoms can also include:

    • Sudden weight loss
    • Fatigue and weakness
    • Fever, chills, sweats
    • Bruising of skin
    • Swollen lymph nodes
    • Headaches
    • Long-lasting infections

    ALL Treatment

    It is of the utmost importance to act quickly when dealing with ALL. By the time the malignancy is diagnosed, chances are it has already spread throughout the body. Unlike other types of cancer, ALL does not form tumors, but because it affects the bone marrow, the malignancy can spread quickly. Treatment for acute lymphoblastic leukemia won’t differ significantly whether the patient is a child or an adult. Some of the most common treatment options for adult acute leukemia include chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant. However, leading medical institutions can offer additional, advanced treatment, such as CAR T-cell therapy.

    Acute Lymphoblastic Leukemia CAR T-cell Therapy

    CAR T-cell therapy is a revolutionary blood cancer treatment that helps the body combat tumors using its own T-cells. The therapy involves collecting the patient’s blood, separating T-cells, and genetically engineering them to produce chimeric antigen receptors (CARs). These allow the T-cells to recognize tumor cells, targeting and destroying them. After their alteration, T-cells are multiplied in a laboratory and reintroduced to the patient’s body.

    At Sheba Medical Center, one of the top 10 hospitals in the world according to Newsweek magazine, the whole treatment process is performed in-house. While other hospitals utilize commercial CARs and have to ship the cells abroad, which can take months, allowing the malignancy to progress and damage the cells, CAR T-cell therapy typically lasts for only around ten days at Sheba, which has already treated over 220 patients with the procedure.

    Reasons to Choose Israel for All Treatment

  • While Israeli and US medical institutions regularly collaborate on advanced research, Israeli facilities tend to integrate new treatments faster, maintaining the highest quality and safety standards.
  • Compared to the US, treatment costs in Israel are 30-80 % lower on average, without sacrificing quality. Israeli medical institutions and physicians are some of the best in the world.
  • Advanced acute lymphoblastic leukemia treatment can be life-saving.

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    Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.

    We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.

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