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Ocular Oncology Treatment

Ocular Oncology Treatment

The Ocular Oncology Center at Sheba Medical Center is the largest center in Israel for the diagnosis and treatment of a variety of ocular tumors and other related conditions. Ocular tumors are rare and can be life-threatening. The treatment for these diseases can be complex, requiring advanced therapies and cutting-edge surgical techniques. We implement a multidisciplinary approach to treat ocular cancer, based on the collaboration of oncologists, hemato-oncologists, radiologists, pathologists, and other Sheba specialists.

Our mission is to save the sight and lives of adult and pediatric patients with ocular tumors, while preserving each patient’s overall health and well-being. The Ocular Oncology Center at Sheba Medical Center is a service of the Goldschleger Eye Institute, located within the hospital’s Division of Surgery, and we operate as a leading national and international referral center.

Ocular Oncology

Diseases We Treat

Ocular/Uveal Melanoma

This is the most common primary cancer of the eye in adults. Called uveal melanoma because it develops in the uveal tract of the eye, it is a malignant and aggressive tumor that can grow and spread to other parts of the body. Just like melanoma of the skin, uveal melanoma can remain silent until it has progressed to a stage where it is difficult to treat effectively.


This cancer begins in the retina, the light-sensitive tissue at the back of the eye. It occurs when retinoblasts grow out of control. If left untreated, the tumors can fill most of the eyeball or break away to form additional tumors on other parts of the eye or spread to lymph nodes and other organs. Retinoblastoma is the most common type of pediatric eye cancer, but it has a high cure rate due primarily to advanced treatments.


This cancer is the most common type of glioma. It is a brain tumor that originates in the astrocytes<, which are star-shaped glial cells that nourish neurons in the brain and protect them from infection. Childhood astrocytomas often form in the visual pathway of the central nervous system. The majority of astrocytomas are highly treatable and highly curable.

Brachytherapy/Radioactive Iodine 125

Also known as plaque therapy, this innovative treatment is only available at a few clinics worldwide, and Sheba is pleased to offer it as an effective therapy for ocular tumors. In Israel, Sheba is the exclusive provider of brachytherapy.

Conventional radiotherapy can damage many healthy cells in the eye, leading to vision loss. Brachytherapy involves placing radioactive iodine 125 plaques directly on the surface of the eye and above the base of the tumor. Advanced computer software enables our doctors to adjust and customize the size of each plaque to optimize it for irradiating the individual’s eye tumor precisely. The plaques are left in place for several days to administer radiation.

Brachytherapy allows controlled, point-to-point irradiation to be delivered to the tumor, thereby minimizing the radiation exposure to healthy retinal areas. This revolutionary therapy helps to preserve the future vision of the treated eye.

In general, brachytherapy and other types of radiotherapy provide exceptional control over ocular tumors. However, studies have shown that uveal melanoma often leads to secondary tumors – even years later. Therefore, all patients treated for uveal melanoma at Sheba’s Ocular Oncology Center are referred for close follow-up surveillance at our Ella Lemelbaum Institute for Immuno-Oncology.

TIL Immunotherapy

TIL (tumor-infiltrating lymphocytes) immunotherapy is a cutting-edge treatment that involves drastically increasing the number of elite cancer-killing lymphocytes in your body that target and attack malignant cells. Patients with ocular melanoma may develop secondary tumors in the future, and if the melanoma metastasizes, TIL immunotherapy can be an effective treatment option.


Some types of ocular cancer cannot be treated with brachytherapy due to their size or location near the optic nerve. In this case, focused external radiation may be delivered via the new, highly progressive LINAC – Linear Accelerator (Novalis-TX), by specialists in the Neurosurgery Unit.


Surgical operations to treat ocular cancer include procedures to remove part of the eye or the entire eye, depending on the location and size of the tumor.


Chemotherapy is generally recommended only when the ocular cancer has become widespread, chemotherapy drugs may be delivered topically, intravenously, intra-arterially, or intravitreally.

Laser treatment

Sometimes, a laser can be used to kill melanoma cells. Thermotherapy, which involves an infrared laser, may be combined with radiation therapy.

Our Staff

Victoria Vishnevskia-Dai, MD
Director Senior Ophthalmologist, Director of the Ocular Oncology and Inflammatory Eye Diseases Service Consultant for the Pediatric Oncology Department, Oncology Institute and Immunology Institute
Dr. Vishnevskia-Dai received her medical degree from the Sackler Faculty of Medicine, Tel Aviv University, and she completed a clinical and surgical fellowship in ocular oncology at the Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA. From 1999-2003, Dr. Vishnevskia-Dai was an instructor in the course on Ocular Diseases Among the Aging Population, at the nursing school of Assaf Harofeh Medical Center.
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Dr. Uzi Nissim
Senior Physician, Department of Neurosurgery
Dr. Nissim, a specialist in radiosurgery, received his medical degree from the Sackler Faculty of Medicine, Tel Aviv University.
A senior physician at Sheba’s Goldschleger Eye Institute
Prof. Ido (Didi) Fabian is a world-renowned expert in ocular tumor treatment, with a particular emphasis on retinoblastoma, lymphoma, and melanoma. Among many other accomplishments, Prof. Fabian founded and leads the Global Retinoblastoma Study Group, co-founded the Asian Retinoblastoma Group, and is the initiator and managing organizer of the ISOO Africa conference – the first meeting of the International Society of Ocular Oncology in Africa.

Sheba’s Holistic Approach to Healing

We believe that successful treatment for people with oncological eye disease results from the compassionate commitment of the attending physicians, the willingness of the patient to undergo the recommended treatment, and the expertise of a multidisciplinary team. At Sheba, we take pride in combining all of these elements to design the most helpful treatment program possible for each patient. We consider all parts of healing – not just the cancer – including the person’s unique psychological, social, and physical needs. Our knowledgeable staff is always available to answer questions and ease the journey for you or your child during the fight against cancer. Additionally, to ensure an efficient, smooth experience, we assign a personal medical coordinator from the International Medical Tourism Division to assist every family.

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Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.

We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.

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