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Stage IV Lung Cancer Treatments in Israel

The Latest Stage IV Lung Cancer Treatments in Israel: Advanced Surgical Options and Immunotherapies

Lung cancer, the most frequently diagnosed cancer in men and the third most common cancer in women, causes more deaths on a yearly basis than any other type of cancer.

Smoking accounts for the majority of lung cancer cases — both in smokers and in people exposed to secondhand smoking, but the malignancy also occurs in people who have never smoked and in those who have never had prolonged exposure to secondhand smoke.

There are two main types of lung cancer – non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), which are classified by how the cancer cells appear under a microscope. Non-small cell lung cancer is the more common of the two by far, comprising about 85-90% of all cases. Small cell lung cancer occurs almost exclusively in heavy smokers, and usually grows and spreads faster.

Stage IV Lung Cancer Treatments in Israel

As with other cancers, to determine each patient’s condition and the best course of treatment, the disease is first staged. Lung cancer cases are categorized by stages on a scale of 0 through IV. the malignancy’s stage is determined by the cancer’s characteristics, such as how large it is and how far it has spread:

| Stage 0

lung cancer is a malignancy limited to the top lining of the lung and has not invaded deeper into other lung tissues.

| Stage I

lung cancer denotes a relatively small tumor that invaded deeper into lung tissues but has not spread to the lymph nodes or other parts of the body.

| Stage II

lung cancer is a somewhat larger tumor that may have spread to the membranes surrounding the lungs, the inner lining of the chest wall, the phrenic nerve, or the parietal pericardium. However, at stage II the malignancy has not spread to distant organs.

| Stage III

lung cancers are large tumors that have spread to the tissues surrounding the lungs, but have not spread to distant organs.

| Stage IV

lung cancer is the most advanced form of the malignancy, and is also the most difficult to treat. In stage IV, the cancer has metastasized from the lungs to other areas of the body. While difficult to treat, stage IV lung cancer treatments are available.

Stage IV Lung Cancer Treatment

Treating metastatic lung cancer is challenging. Stage IV lung cancer can continually spread, and small remnants of the malignancy may linger in the body and cause a recurrence even when treatments seem successful. Stage IV lung cancer treatments typically include chemotherapy, radiation therapy, surgery, hormone therapy, targeted therapy, and immunotherapy.

At Sheba Medical Center, our skilled surgeons, pulmonologists, pathologists, medical oncologists, and radiation oncologists collaborate to design the most effective personalized treatment program based on the type and stage of the malignancy. When surgical removal is indicated as the best treatment option, we offer the most advanced lung surgery procedures for cancer patients, making use of the latest robotic surgical systems.

While the surgical approach is usually chosen when possible, its efficacy is often limited when dealing with metastasized cancers. One advanced solution for lung cancer, available in select medical facilities, is immunotherapy.

Keytruda: Lung Cancer Immunotherapy

Cancer immunotherapy describes a variety of treatments that utilize your body’s own immune system to fight the disease. These treatments work in several different ways – either by boosting your immune system in general or by stimulating your immune system to recognize and attack specific cancer cells. In recent years, immunotherapy has become an essential part of treating certain types of cancer and often works when other treatments have failed.

At Sheba Medical Center, we offer patients a range of lung cancer immunotherapies, administered based on each patient’s specific cancer pathology to ensure optimal immune response. One of these advanced treatments is Keytruda, a monoclonal antibody that disables the cancer cells’ ability to hide from the immune system, allowing it to target and destroy cancer cells. As an advanced, cutting-edge treatment, Keytruda is offered in only a few select medical facilities globally.

Stage IV Lung Cancer Treatment in Israel: The Benefits

Advanced Treatment:

Medical institutions in Israel and the US often collaborate in cutting-edge cancer research, developing new and effective treatments against the disease, yet Israel has fewer constraints than the US when it comes to adopting novel therapies. Israeli clinical trials still adhere to the highest safety standards, but innovative treatments are generally made available to patients sooner than in the US.

Quality of Care:

Israeli physicians are exceptionally well-trained and often spend even more time on their medical education than American doctors. Also, you can be assured of high standards and strict safety regulations if you choose a hospital accredited by a trustworthy authority.


In many countries, healthcare costs can be exorbitant. Without insurance, the costs of cancer treatment can be crippling. Prices are much lower in Israel, averaging 30-80% less than in the US, for example. That said, you’re not trading affordability for quality, since Israeli specialists, medical institutions, equipment, and procedures are among the most advanced in the world.

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Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.

We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.

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