Sheba Medical Center and International Research Partners Conquer a New Frontier in the Fight Against Cancer
The collaboration of elite medical researchers from Sheba and six international partners pioneered the path for a new, revolutionary cancer treatment. For the first time ever, these researchers conducted a successful clinical trial using genomic and transcriptomic profiling (RNA expression testing) to advance precision cancer medicine. This clinical trial, called the WINTHER trial, was designed by the WIN Consortium, and one of the lead researchers is Dr. Raanan Berger, MD, PhD, Director of Oncology at Sheba.
During the clinical trial, 69 patients were given treatments based on DNA mutation profiling, and 38 patients were given RNA profiling treatments. At the end of the trial, the results showed that 35% of the patients were matched successfully with personalized therapy. In contrast, earlier studies did not demonstrate as high of a success rate in matching. The WINTHER researchers demonstrated the safety and efficacy of using RNA expression and normal tissue biopsy to customize therapy options for patients.
“Importantly, our results show that patients treated with a drug or regimen more closely matched to the molecular profile of their tumor, do better,” said Razelle Kurzrock, co-leader of the WINTHER trial and Director of UCSD Moores Center for Personalized Cancer Therapy.
Along with Dr. Berger from Sheba, the skilled team responsible for conducting the WINTHER trial included researchers from: Vall d’Hebron Institute of Oncology – VHIO, in Spain; Gustave Roussy, in France (Jean-Charles Soria); Centre Léon Bérard, in France (Pierre Saintigny); Segal Cancer Centre, McGill University, in Canada (Wilson H. Miller); UT MD Anderson Cancer Center, in the USA (Jordi Rodon and Apostolia-Maria Tsimberidou); and University of California San Diego, Moores Cancer Center, in USA (Razelle Kurzrock).