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Sarcoma Treatment Options: What Makes Sheba a Wise Choice?

Sarcoma Treatment Options: What Makes Sheba a Wise Choice?

Sarcoma is the collective term for a broad range of cancers that develop in the bones and soft tissues that connect, support, and surround other body structures.

The tissues typically affected by the disease include bones, cartilage, tendons, muscles, fibrous tissues, nerves, fatty tissues, arteries, veins, and skin. There are more than 70 types of sarcomas that comprise about 1% of all malignant diseases, and range from slowly developing to aggressive and rapidly growing.

Different types of sarcomas are usually categorized according to where the cancer forms. In general, bone sarcomas are more common among children, while soft tissue sarcomas, typically found in the arms, legs, chest, or abdomen, are more prevalent in adults.

Sarcoma cases are categorized by stages on a scale of I through IV. The stage is determined by the tumor’s size and how far cancer has spread, while sarcoma treatment options vary depending on the malignancy’s stage, location, and other factors.

Advanced Sarcoma Treatment

Sarcoma Treatment Options

In general, sarcoma treatment options may include chemotherapy, targeted therapy, radiation therapy, immunotherapy, and surgery. Some patients may develop advanced, metastatic sarcomas that are resistant to conventional therapies, in which case more innovative treatments are needed. When treating stage IV bone sarcomas, the surgical approach may not be viable, in which case more systemic treatments, such as hormone therapy, targeted therapy, and chemotherapy, are preferred. At Sheba, within our Department of Sarcomas and Bone Tumors, we provide several advanced therapeutic modalities and are actively involved in clinical studies that examine and develop treatments for sarcoma at the metastatic stage.

Sarcoma Immunotherapy

By encouraging the patient’s own immune system to attack cancer cells, immunotherapy provides effective treatment while minimizing side effects. Immunotherapy takes several forms, including injectable vaccines, biological drugs, and cell transfers.

At Sheba, we offer several immunotherapies for sarcoma, one of which is MEPACT, which stimulates the immune system to destroy cancer cells by promoting the production of certain white blood cells called monocytes and macrophages.

Sarcoma Targeted Therapy

Targeted therapies are drugs that interfere with the way that cancer cells grow. They can include cancer growth inhibitors and monoclonal antibodies. They are particularly useful when regular chemotherapy has not been effective, and many research studies are now exploring their application as a treatment for primary bone cancers.

At Sheba, we offer cutting-edge sarcoma-targeted therapies, including tyrosine kinase inhibitors (TKIs), such as imatinib, used as a first-line treatment for people with gastrointestinal stromal tumors. The treatment is usually chosen when cancer cannot be completely removed with surgery or has spread prior to surgery.

Pazopanib is another TKI provided at Sheba, which may be used to treat advanced metastatic soft tissue sarcoma.


Another breakthrough targeted treatment offered at Sheba, antiangiogenesis, inhibits the development of blood vessels that feed metastases. This safe and efficient drug cocktail is administered orally at home, and according to studies, in 46% of patients treated with antiangiogenesis, around a third of the metastases stopped growing. Even more significantly, 15% of the patients showed a substantial reduction in the size of metastases.

Robotic Surgery

Surgery often constitutes the first line of stage IV sarcoma treatment. However, inadequate surgical excision is a common problem. At Sheba, we provide robotic or robot-assisted surgery, which allows doctors to perform complex, minimally invasive surgical procedures with precision and accuracy through the use of robotic arms. These arms are controlled by the surgeon through a dedicated console.

Widely accepted as one of the most advanced surgical systems available, the new da Vinci Xi represents the 4th generation of robotic surgical technology, taking surgical treatment to an entirely new level.

Greatly contributing to the precise detection and removal of tumors, advanced surgical robotic systems, such as the da Vinci Xi offer many sarcoma patients new hope for a full, healthy life. At Sheba, we are proud to stand at the forefront of surgical innovation and operate many advanced robotic systems, including the da Vinci Xi.

Sarcoma Treatment Options

Sheba’s Sarcoma Specialists

Sheba clinicians include some of the world’s leading experts in the field:

Rony Weitzen

Dr. Rony Weitzen, Director of the Department of Sarcoma and Bone Tumors.

Dr. Weitzen specializes in clinical oncology, radiotherapy, bone tumors, and sarcomas. With immunotherapy fellowships in Germany and the United States under his belt, Dr. Weitzen also serves as an oncology lecturer at Tel Aviv University’s Sackler School of Medicine.

Boaz Liberman

Dr. Boaz Liberman, Director of the Orthopedic Oncology Unit

An expert in orthopedic oncology, sarcomas, and joint replacement, Dr. Liberman completed adult reconstruction surgery and orthopedic oncologic surgery fellowships at Mount Sinai Hospital, and specializes in magnetic resonance-guided ultrasound surgery, sarcoma cell lines, revision arthroplasty, bone metastasis reconstruction, and serum markers in bone sarcoma.

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Choosing Sheba for Sarcoma Treatment

Nowadays, cancer patients have plenty of options to choose from when it comes to medical care, and it is vital to make an informed decision. Sheba Medical Center, ranked by Newsweek among the world’s top 10 hospitals for the past four years, is an international leader in medical innovation, particularly in the field of cancer care: collaborating with medical centers around the globe to develop groundbreaking techniques and life-saving treatments.

The largest medical center in Israel, serving more than 100,000 patients a year, Sheba is home to the most advanced cancer care, with a multidisciplinary team that offers cutting-edge, personalized sarcoma treatment options.

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Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.

We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.

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