PIPAC – Innovative Peritoneal Metastasis Treatment in Israel
PIPAC is an innovative drug-delivery method that can be highly effective at controlling peritoneal (abdominal) metastasis and certain types of cancer – without the undesirable side effects of other conventional therapies. When combined with regular chemotherapy, PIPAC can not only help with palliation, but also prolong life for many cancer patients. At Sheba Medical Center, our team in the Department of Surgical Oncology (Surgery C) comprises experts who have undergone specialized, high level training in PIPAC.


How does PIPAC work?
PIPAC is a minimally invasive laparoscopic surgery performed under general anesthesia. The leading-edge technology uses a video camera and the Capnopen, a customized nebulizer device. Capnopen pressurizes the chemotherapy agents, transforming them into an aerosol. The primary benefit of PIPAC is that a smaller dosage of cytotoxic agents is required, because the aerosolized delivery penetrates deeper into the tumor tissue.
Why choose Sheba for PIPAC?
World-class physicians
our surgical oncologists learned PIPAC directly from the doctors who invented and developed this breakthrough treatment
Affordable cancer care
top value at costs that are much lower than in Europe, with no hidden fees
Efficient & patient-friendly
every patient is assigned a personal coordinator from our Global patient services, who will help with every detail of your treatment at Sheba
Collaborative medicine
our skilled staff is comprehensive, and a multidisciplinary team of experts work together to provide integrative, personalized treatments
Internationally recognized
Sheba is fully accredited by the Joint Commission International (JCI), the gold standard in healthcare
Leading-edge campus
our hospital departments feature state-of-the art technologies and the latest therapies
Sheba – Ranked In The Top Ten Best Hospitals Worldwide
Meet Our Doctors
The physicians at Sheba Medical Center’s Department of Surgical Oncology (Surgery C) are internationally renowned cancer experts who apply their premier training, unique experience, and dedicated approach to treating every patient.

Prof. Aviram (Avi) Nissan, MD
Head of Department of Surgery C
Prof. Nissan is a world-recognized physician in Oncological Surgery, with particular expertise in complex tumors of the digestive system. He is a leading specialist in HIPEC treatment of abdominal metastasis, and he is one of the first doctors to learn PIPAC and bring it to Israel.
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Almog Ben-Yaacov, MD
Senior Surgeon, Department of General and Oncological Surgery-Surgery C
Dr. Ben-Yaakov specializes in CRS and HIPEC procedures, gastric cancer, sarcomas, and complex colorectal malignancies. By 2018, he had performed over 200 HIPEC procedures under the guidance of Prof. Nissan, a world-renowned specialist in CRS and HIPEC.
Read MoreHolistic Healthcare for the Whole Patient
Our Department of Surgical Oncology (Surgery C) is the first facility in Israel to offer custom-tailored cancer treatments based on a truly holistic approach. We consider all of your needs – physical and emotional – when you visit Sheba for PIPAC and other cancer therapies. Our multidisciplinary staff pays attention to the various ways in which your condition challenges your quality of life, and we strive to find solutions to meet your overall needs. While all of our treatment programs are designed using scientifically confirmed facts and cutting-edge Western medicine, we also offer complementary treatments. In addition to doctors, our caring staff includes nutritionists, physiotherapists, professional nurses, and psychologists.
Request a consultation
Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.
We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.
Request a consultation and a Sheba Case Manager will contact you shortly: