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Patient Knowledge Base

Can Waldenstrom’s become multiple myeloma?

Waldenstrom’s macroglobulinemia (WM) and multiple myeloma are distinct conditions, both involving abnormal proliferation of white blood cells. WM involves B cells, while multiple myeloma involves plasma cells. While both diseases can manifest with high protein levels in the blood and share some symptoms, they are separate entities with different clinical courses and treatments. It’s not typical for WM to “become” multiple myeloma. However, having one doesn’t preclude developing the other, although this would be rare.

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