FAQ: Does CAR T-cell therapy have any side effects?

CAR T-cell therapy can lead to several side effects, some of which can be severe. One common side effect is cytokine release syndrome (CRS), which occurs when the activated CAR T-cells release large amounts of cytokines, leading to flu-like symptoms such as fever, fatigue and low blood pressure. Neurologic toxicity is another potential side effect, causing confusion, seizures, or difficulty speaking. Additionally, patients may experience hematologic toxicity, leading to low blood cell counts. While these side effects can be managed, it’s essential for patients undergoing CAR T-cell therapy to be closely monitored and receive appropriate medical support.