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Melanoma and Skin Cancer Treatment in Israel

Melanoma typically develops in the skin, and it is one of the most aggressive types of skin cancer. Fortunately, the treatments have a very high success rate when melanoma is discovered early. At the Ella Lemelbaum Institute for the Treatment and Research of Melanoma and Skin Cancer at Sheba Medical Center, our world-class team specializes in diagnosing and treating melanoma patients with integrative, compassionate care. We are actively engaged in advanced research and therapies for this disease.

sheba hospital is a highly advanced Medical center in Israel and is ranked best among hospitals in Israel
Melanoma and Skin Cancer Treatment in Israel

Specific Melanoma Treatments at Sheba

We provide melanoma treatment for all stages of the cancer:

    Early stage treatment – surgical removal is the primary treatment

    Treatment when skin penetration is less than 1mm – additional surgery to remove cancerous cells surrounding the initial lesion

    Treatment when skin penetration is greater than 1mm – removal of local lymph nodes and various therapies to prevent metastasis

    Metastatic melanoma – a variety of therapies, including biological drugs, chemotherapy, TIL immunotherapy, and surgery.

Over 10 research studies are presently ongoing at the Ella Institute, and we conduct personalized evaluations to determine patient eligibility.

Reasons to Choose Sheba for Melanoma Treatment Center

Leading International Center

we are recognized worldwide as a top treatment center for melanoma, working in conjunction with the National Institutes of Health in the United States

Latest Therapies

breakthrough treatments and the opportunity to enroll in active clinical studies

Advanced Technology

state-of-the-art equipment to ensure precise diagnoses and treatment

Patient centric

customized treatments to suit every individual’s condition and personal needs

Personal Coordinator

our International Medical Tourism Division will provide you with a supportive coordinator who will facilitate your efficient experience from start-to-finish

Sheba Medical Center Transforming Healthcare and Biomedical Innovation

Standing at the forefront of clinical research, innovation, and patient care, Sheba Medical Center, the largest hospital in the Middle East, continues to set the standard for international excellence. For the fifth consecutive year, Newsweek ranked Sheba as one of the world’s best hospitals, as well as listing the medical center as one of the best smart hospitals and a leader in gastroenterology, neurology, and cardiology. Committed to advancing patient care and transforming healthcare worldwide, Sheba continually pushes boundaries in research and clinical care.

Special Treatments Available at Sheba

We are the only hospital outside of the United States to offer Tumor-Infiltrating Lymphocytes (TIL) Immunotherapy, a new experimental treatment for patients with metastatic melanoma. This progressive treatment shows great promise for melanoma that has spread beyond the outermost layers of skin.

Fecal microbiota transplant

A gut microbiome is the totality of microorganisms, bacteria, viruses, protozoa, fungi, and their collective genetic material present in each person’s gastrointestinal tract. Recently, scientists discovered that the microbiome works closely with the immune system so that a change in the flora of the bacteria has an effect on the body’s immune response to many health conditions, including treatments for oncological diseases. By eradicating the microbiota of a melanoma patient who is unresponsive to immunotherapies and replacing it with bacteria taken from melanoma patients who have responded to the treatment, through the use of a fecal transplantation, this procedure can significantly improve a patient’s body’s responsiveness to immunotherapy.


The innovative Immunophoresis approach uses a special filter to remove specific immune-suppressive cytokines produced by cancer tumors. Selective removal of these targeted cytokines is intended to neutralize the cancer’s ability to block natural immune defense mechanisms, which are significantly compromised during late-stage, metastatic cancer. In this manner, the treatment re-energizes the immune system to aggressively fight the malignancy. An added benefit lies in the relative lack of side effects or detrimental impact on quality of life typical of other cancer treatments.

Innovation & Research - Sheba Medical Center

Meet Our Doctors

gal markel (2)

Gal Markel, MD

Director of the Ella Lemelbaum Institute for Immuno-Oncology

Prof. Markel is a medical oncologist, an Associate Professor in Clinical Microbiology and Immunology at the Sackler School of Medicine at Tel Aviv University and the Head of the Research laboratory at the Ella Lemelbaum Institute for Immuno-Oncology.

Ronnie Shapira

Ronni Shapira, MD

Oncology Specialist, The Ella Institute for the Treatment and Research of Melanoma and Skin Cancer

Dr. Shapira is a leading oncologist in Israel. She received her medical degree from the Sackler School of Medicine at Tel Aviv University.

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Our Holistic Approach

When treating cancer, we treat the whole patient. Our team of specialists consists of medical oncologists, dermatologists, pathologists, surgeons, and researchers. This enables us to serve you with the best healthcare possible for superior results. With consideration for the challenging effects of cancer therapies, we strive to improve your quality of life throughout treatment.

Request a consultation

Sheba Medical Center provides innovative, personalized medical care to patients from around the world. We are the largest, most comprehensive hospital in the Middle East and dedicated to providing advanced and compassionate medicine for everyone.

We welcome all cases, including the rarest and the most challenging. Our medical teams collaborate to provide the best possible health outcomes. From your initial inquiry through the long-term follow-up care, we are here for you.

Request a consultation and a Sheba Case Manager will contact you shortly: