REQUEST A CONSULTATION

Ready to contact us for a consultation about your condition and our medical services? The staff of our Global Patient Services is ready to help. Please select the appropriate button to get started.
search

From Uncertainty to Hope: Elena’s Journey With CAR-T Therapy

Elena with her family before starting CAR T Cell Therapy at Sheba
At just 21, Elena Sevastiyanova’s life was full of dreams, studying agriculture in Bulgaria, spending time at the beach, hoping to one day manage her family’s vineyards and buy a horse. But when illness struck, her mother’s insistence on medical testing revealed a daunting diagnosis: a tumor in Elena’s heart caused by B-cell non-Hodgkin lymphoma. With her family’s steadfast support, they began a determined search for advanced treatment worldwide and landed upon Sheba.

Elena’s treatment journey began in Bulgaria with chemotherapy, Mabthera, and immunotherapy. Yet, a stubborn tumor spot in her left lung dimmed hopes for a full recovery.

A Race Against Time: Seeking Care Across Borders

Determined to find more advanced and responsive care, the family traveled to Türkiye. There, after two cycles of chemotherapy, the Turkish doctor recommended exploring CAR T-cell therapy. Hoping for a breakthrough, they pursued a referral to a leading world-renowned hospital in Europe. However, their hopes were met with silence, calls went unanswered, and critical time slipped away.

In a pivotal moment of urgency, after getting in contact with Sheba Medical Center in Israel, Maya, Elena’s mother, received a call within just one hour from Jozef, a case manager from Sheba. Maya said that Sheba’s response was “speed[y]” and “exceptional.”

This swift and compassionate response transformed the family’s anxiety into decisive action. At Sheba, Elena found not only the advanced CAR T-cell therapy her condition required, but also a team dedicated to making her care seamless, personal, and hopeful. This experience embodies Sheba’s commitment to patients worldwide, a blend of clinical excellence, rapid responsiveness, and human warmth, making the difference when time is critical.

Elena during CAR T Treatment at Sheba Medical Center

Expert Care With A Personal Touch: Treatment at Sheba

Under the compassionate guidance of Dr. Ronit Marcus, a senior hemato-oncologist at Sheba, Elena embarked on her CAR T-cell therapy journey as part of Sheba’s advanced clinical research program. Her mother, Maya, deeply appreciated Dr. Marcus’s urgency and professionalism, noting how he emphasized the critical importance of starting treatment without delay to maximize Elena’s chances of recovery.

Integral to this journey was Elena’s coordinator, Rima, whose role went far beyond logistics. More than just a coordinator, Rima became like family, offering unwavering emotional support, practical guidance, and steady reassurance throughout every step of treatment. Maya described the difference at Sheba as “highly professional, flexible, responsive, and deeply personal,” a combination that eased the family’s fears and provided a sense of safety in a foreign country. Sheba’s Global Patient Services supports international patients by providing comprehensive travel logistics, including translation services and continuous coordination throughout the treatment journey to ensure a seamless, personalized experience from arrival to follow-up care.

Maya especially highlighted the warmth and mental strength of the Sheba team, qualities that helped transform her initial anxieties into trust and hope. Despite the challenges of being far from home, the environment at Sheba felt safe and nurturing. When asked about Elena’s experience, Maya shared that her daughter’s constant response to “How are you?” was simply, “Fine,” reflecting a quiet optimism and inner strength.

This resilience deeply inspired Maya herself, who said, “If she is so strong, I must be strong, too.” Together, their bond and the compassionate, expert care at Sheba Medical Center created a foundation not only for healing the body, but strengthening the spirit, illustrating the center’s holistic approach to patient-centered care.

A New Chapter Begins

Recently, at a follow-up appointment at Sheba’s Global Patient Services office, Elena’s scans were clear, and she looks and feels good, embracing life with the optimism of any young woman her age.

Elena’s story highlights how expert, compassionate care combined with cutting-edge therapies like CAR-T can transform lives. At Sheba, patients are not just treated; they are supported holistically with a 360-degree approach, surrounded by a team dedicated to healing and hope.

For families facing the devastating challenge of serious illness, placing trust in expert, compassionate care is not just important, it can be transformative. Elena’s journey shows that even amid uncertainty and fear, hope can take root when surrounded by a dedicated medical team who act swiftly and skillfully. The path from diagnosis to recovery is rarely straightforward, but with perseverance, access to cutting-edge treatments, and emotional support, patients and their families can find strength and healing that open a new chapter in their lives. Elena’s story is a powerful reminder that recovery is possible and that expert care combined with hope can profoundly change lives.


If you or a loved one is seeking treatment for B-cell non-Hodgkin lymphoma, reach out to Sheba’s Global Patient Services for a free consultation.

Related
Surgeons performing robotic heart surgery at Sheba Medical Center in Israel
First Robotic Heart Surgery in the Middle East Performed at Sheba Medical Center
A landmark procedure at Sheba Medical Center has brought robotic heart surgery to Israel and the Middle East for the first time, offering a less invasive, lower-risk alternative to traditional open-heart surgery, and expanding access to cardiac care for patients who need it most.
Read More
Forbes Israel Best Doctors 2025 recognizing Sheba hematology experts
News Mar 02.
Inside Sheba’s Hematology Ecosystem: Expertise Recognized by Forbes Israel
Forbes Israel’s 2025 ‘Best Doctors’ list has recognized several hematologists and hemato-oncologists from Sheba Medical Center, reinforcing the institution’s position as a global leader in complex, high-risk care. This peer-driven acknowledgment highlights the strength of Sheba’s hematology ecosystem, where clinical leadership, research engagement, and multidisciplinary collaboration contribute directly to the hospital’s international rankings and reputation.
Read More
Sheba Medical Center Rises to #7 in the World's Best Hospital Rankings
Sheba Medical Center Rises to #7 in the World's Best Hospital Rankings
At Sheba, Patients Come First At Sheba Medical Center, the patient is at the heart of everything. This guiding principle shapes every treatment plan, drives…
Read More