The Riva Koschitzky Oncology Clinical Research Unit
Oncology Clinical Research Unit
The Riva Koschitzky Oncology Clinical Research Unit, recognized as a center of excellence at Sheba Medical Center, supervises the operation of all clinical trials conducted within the Cancer Center. Groundbreaking studies are performed, with results that are translated into the developing innovative treatments and progressive diagnostics. Approximately 160 basic and clinical trials are done yearly, often in conjunction with leading international cancer research facilities. Clinical oncology research at this center enables patients to access innovative treatments not yet available outside of scientific trials.

The Cancer Center – Sheba Medical Center
The Riva Koschitzky Oncology Clinical Research Unit is located in the Cancer Center at Sheba Medical Center, Israel’s leading facility for oncology treatment, radiotherapy and research. Approximately 4500 patients are treated yearly, and thousands of cancer patients visit for follow-up procedures and tests. The clinical staff comprises a roster of world-renowned physicians, all of whom specialize in treating specific types of cancer.
The Cancer Center includes the following departments:
- Riva Koschitzky Oncology Clinical Research Unit Ella Institute for Treatment and Research of Melanoma and Skin Cancer
- Radiation Oncology Department >
- Meirav Breast Center >
- Sheba Pancreatic Cancer Center – SPCC
What Do Our Laboratories Offer?
The Laboratory Division at our clinical oncology research unit comprises 35 laboratories that cover all medical specialties, including clinical biochemistry, hematology and clotting, bacteriology, virology, pathology, toxicology and clinical pharmacology, blood bank and transfusion medicine, endocrinology, histology, human genetics, hemodynamics, molecular diagnostics and emergency testing. Ten of our laboratories are accredited by the Israel Laboratory Accreditation Authority, compliant with ISO 15189 standards.
The research infrastructure at Sheba Medical Center includes:
- The Institutional Tissue Bank (ITB), which provides researchers with high-quality and well-annotated bio-specimens (plasma, fresh frozen, paraffin embedded)
- Good Tissue Culture Practice Laboratory (GTP)
- Specific pathogen free animal house (SPF)
- Close interaction with the Cancer Research Center at Sheba
- Molecular diagnostics lab
We also feature a Center for Translational Research in Radiation Oncology, with a fully equipped radiobiology lab (including a small animal irradiator) for designing and conducting early phase clinical trials involving radiation therapy.
What Types of Trials Do We Conduct?
The Riva Koschitzky Oncology Clinical Research Unit is divided into two highly specialized sections that conduct precise academic or industry sponsored trials:
Early-Phase Research
The unit for Early Phase Trials was established in 2009, for the sake of testing new drugs and treatments. Merck Sharp & Dohme selected Sheba’s center to be a part of its global network of 19 leading cancer centers for early phase R&D. Our unit is a referral center for oncology phase I clinical trials.
A specialized, highly qualified staff (medical director, clinical research manager, two dedicated study coordinators, a study nurse) operates this unit. Additionally, the Ministry of Health has established a special fast approval process for oncology phase I trials.
Late-Phase Research
Studies at this unit are initiated by institute researchers and conducted in partnership with a variety of multinational pharmaceutical firms, international oncological associations and startup ventures. It also operates in close cooperation with other hospital departments, such as imaging, pathology, nuclear medicine and pharmacy. Currently, about 60 oncological Phase II, III, and IV clinical trials are underway; approximately 25 new trials are approved annually, and 100-200 new patients are enrolled each year. Research inception time is short – about 4-5 months from submission to approval. All external audits have been successful.
The Department Manager

Prof. Raanan Berger, MD, Ph.D
Our Doctors

Yaacov Lawrence, MD

Talia Golan, MD
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